Antiprotozoal agents

Eflornithine (α-difluoromethylornithine or DFMO) is a drug manufactured by Sanofi-Aventis which has various uses. It was initially developed as a cancer medication; and while it has no significant effects on cancerous malignancies, it was found to be very effective in combatting African trypanosomiasis (sleeping sickness), in particular the West African form of the disease. It is hoped that eflornithine will replace the relatively toxic melarsoprol. Supplies of Eflornithine are limited as it is not very cost effective to manufacture. Aventis stopped making eflornithine in 1995 because of this very reason. The drug company gave the rights to manufacture the drug to the World Health Organization, who attempted to find a new supplier. Eflornithine is also an effective hair removal agent and is the active ingredient in Vaniqa brand hair removal cream. ...more on Wikipedia about "Eflornithine"

Furazolidone (also marketed as Furoxone) is an antibiotic used to treat diarrhea and enteritis caused by bacteria or protozoan infections. ...more on Wikipedia about "Furazolidone"

Melarsoprol (2-[4-{(4,6-Diamino-1,3,5-triazin-2-yl)amino}phenyl]-1,3,2-dithiarsolan-e-4-methanol) is a medicinal drug used in the treatment of African trypanosomiasis, also known as sleeping sickness. It is also sold under the trade names "Mel B" and "Melarsen Oxide-BAL". Melarsoprol is a highly dangerous treatment, only administered by injection under the supervision of a physician. It causes a range of side effects, among them convulsions, fever, loss of consciousness, rashes, bloody stools, nausea, and vomiting. It is fatal in and of itself in a significant percentage of cases. Eflornithine is a more modern and far less dangerous treatment for sleeping sickness, but is expensive, not widely available on the market, and most of its supply comes from donations from its manufacturer. Melarsoprol is often refered to as " arsenic in antifreeze" due to its composition and its unpleasant effects on patients. ...more on Wikipedia about "Melarsoprol"

Metronidazole is an antibiotic and antiprotozoal drug classified as a nitroimidazole. It inhibits nucleic acid synthesis and is used for the treatment of infections involving anaerobic bacteria as well as protozoal infections. ...more on Wikipedia about "Metronidazole"

Ornidazole is a drug that cures some protozoan infections. It is used by the poultry industry. ...more on Wikipedia about "Ornidazole"

Paromomycin sulfate (brand name Humatin) is a drug that fights intestinal amoeba infection, or amebiasis. ...more on Wikipedia about "Paromomycin sulfate"

Pentamidine isethionate is an antiparasitical/antiprotozoal drug primarily given for prevention and treatment of Pneumocystis jiroveci pneumonia, also formerly known as Pneunocystis carinii pneumonia (PCP), a type of pneumonia often seen in patients with HIV infection. PCP is considered an 'opportunistical infection', endagering only immunecompromised patients such as those with HIV/AIDS-infection. The mortality of untreated PCP is very high. Additionally, Pentamidine has good clinical activity against the parasites causing Leishmaniasis. Sleeping sickness caused by different strains of Trypanosoma is another indication. The exact nature of its antiprotozoal action is unknown. The drug has also activity against candida albicans in clinically relevant concentrations. In the US Pentamidine is currently designated an orphan drug by the FDA. ...more on Wikipedia about "Pentamidine"

Pyrimethamine (Daraprim®) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention), and is also used in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. ...more on Wikipedia about "Pyrimethamine"

Tinidazole is a prescription drug used against protozoan infections. ...more on Wikipedia about "Tinidazole"

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