Medicinal chemistry Medicinal chemistry Drug design is the approach of finding drugs by design, based on what the drug is targeting. Typically a drug target is a key molecule involved in a particular metabolic or signalling pathway that is specific to a disease condition or pathology. ...more on Wikipedia about "Drug design"
In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. ...more on Wikipedia about "Drug discovery"
The Journal of Medicinal Chemistry (usually abbreviated as J. Med. Chem.), is a peer-reviewed scientific journal, published since 1959 by the American Chemical Society. It was origonally published as the Journal of Medicinal and Pharmaceutical Chemistry, but changed its name in 1963 to the current title. ...more on Wikipedia about "Journal of Medicinal Chemistry"
In 1997 Christopher A. Lipinski published a seminal paper identifying a series of features commonly found in orally active drugs. These features are referred to as Lipinski's rule of five and can be used as a rule of thumb to indicate whether a molecule is likely to be orally bioavailable (bioactive) (See also ADME). The "rule of five" is so called because most of the features start with the number five. ...more on Wikipedia about "Lipinski's Rule of Five"
Some criteria for editing this page have been debated and are displayed on the talk page. Please consult them before editing. ...more on Wikipedia about "List of publications in chemistry"
LogP is a measure of differential solubility of a compound in two solvents. The log ratio of the concentrations of the solute in the solvent is called LogP or the Partition Coefficient. The most well known of these partition coefficients is the one based on the solvents Octanol and Water. The octanol-water partition coefficient is a measure of the hydrophobicity and hydrophilicity of a substance. In the context of drug-like substances, hydrophobicity is related to absorption, bioavailability, hydrophobic drug- receptor interactions, metabolism and toxicity. ...more on Wikipedia about "LogP"
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). ...more on Wikipedia about "Medicinal chemistry"
According to the U.S. Food and Drug Administration, a "new chemical entity means a drug that contains no active moiety that has been approved by FDA in any other application submitted under section 505(b) of the Federal Food, Drug, and Cosmetic Act." ...more on Wikipedia about "New chemical entity"
A pharmacophore was first defined by Paul Ehrlich in 1909 as "a molecular framework that carries (phoros) the essential features responsible for a drug’s (pharmacon) biological activity" (Ehrlich. Dtsch. Chem. Ges. 1909, 42: p.17). In 1977, this definition was updated by Peter Gund to "a set of structural features in a molecule that is recognized at a receptor site and is responsible for that molecule's biological activity" (Gund. Prog. Mol. Subcell. Biol. 1977, 5: pp 117–143). ...more on Wikipedia about "Pharmacophore"
QSAR (quantitative structure-activity relationship, sometimes the A stands also for affinity = reactivity) is the quantitative correlation of the biological ( ecological, toxicological or pharmacological) activity to the structure of chemical compounds, which allows the prediction of the so-called " drug efficacy" of a structurally related compound. It is thus closely related to the more general field of QSPR and employs many of the latter's methodology. ...more on Wikipedia about "Quantitative structure-activity relationship"
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